Results: No significant differences between CSII and SAP in third trimester HbA1c (6.4 ± 0.7% vs. 6.5 ± 0.6%) and perinatal outcome (pre-term delivery, macrosomia, neonatal hypoglyce-mia, NICU admission) were found. (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) were measured. Children tend to underestimate their IAH compared to their parents. HbAlc level doesn't correlate with the patient's income or education level. Patients were categorised into 3 groups based on HbA1c, [<7.5%/58mmol/mol (n=58); 7.5-8.9%/58-74mmol/mol (n = 107) and > 9.0%/75mmol/mol (n=36)]. 1. Background and Aims: 2-5% of pregnancies in the UK are complicated by diabetes. Ortsuche finden Sie auch Ansprechpartner im Ausland. Method: We developed a calorimetry-based small storage device, which fits all existing pens and vials. Hypertensiologe DHL® . The mean glucose level over all is 131 mg/dL with a standard deviation of 46. recurrence is frequent. This dilemma has raised the question as to whether the b-cell is the ''target of homicide'', i.e. Bolli7, 1Oregon Health & Science University, Department of Medicine, Portland, USA, 2Newcastle University, Institute of Cellular Medicine -Diabetes, Newcastle upon Tyne, United Kingdom 3University of Padova, Department of Medicine, Padova, Italy 4Hospital Clinic of Barcelona, Diabetes Unit - Endocrinology Department, Barcelona, Spain 5Sanofi, Diabetes Division, Paris, France, AIXIAL, Biostatistics, Levallois-Perret, France University of Perugia, Medicine, Perugia, Italy. In short-duration diabetes, the DCCT and UKPDS have clearly shown that in glucose control defined as HbA1c can predict mi-. TIDEPOOL: AN OPEN SOURCE, EXTENSIBLE PLATFORM FOR DIABETES MANAGEMENT AND RESEARCH, 1Tidepool, Corporate Research and Development, Palo Alto, USA. There was also a strong association of OH and the prevalence of peripheral artery disease in both DM1 (OR = 14.18) and DM2 (OR=3.26). Method: Seven diverse clinical sites were recruited representing different practice styles from across the United States, all with large Type 1 DM populations (n = 140 patients and 17 clinicians). At 3 months, median A1c was similar (7.6 vs. 7.6, p=0.89). Subjects using CSII were significantly younger than subjects using MDI (36.3 ± 12.6 years old vs. 47.5 ± 16.7 years old, P < 0.001), and the initial HbA1c level was significantly lower (8.4± 1.9% vs. 9.7 ±2.6%, P<0.001), however the ratio of male was not significantly different (29.0% vs. 37.9%, P=0.209). IQR and CV did not reach significant difference (P > 0.09). 5Universidad Autonoma de Nuevo Leon, University Hospital, 6University of Nantes, Endocrinology, Nantes, France, 7University of Texas Southwestern Medical Center and, Parkland Health & Hospital System, Internal Medicine -, Background and Aims: The EDITION 1,2 and 3 clinical trials showed that insulin glargine 300U/mL (Gla-300) provided com-. Niepubliczny ZOZ, Stacja Dializ International There was no difference in risk of severe hypoglycemia (BG < 40 mg/dl) and no difference in mean length of stay. Conclusion: These preliminary findings suggest that daily stressors can be associated with increased glucose instability and hypoglycemia, as well as decreased carbohydrate consumption. Method: A model of the beta-cell insulin secretion and a model of the alpha-cell glucagon secretion were selected for this purpose. THE DAILY NEED FOR INSULIN IN PREGNANT WOMEN WITH TYPE 1 DIABETES, RECEIVING INSULIN WITH INSULIN PUMP, F. Valeeva1, J. Sharipova1, Z. Alimetova1, L. Gaysina1, 1Kazan State Medical University, endocrinology, Kazan, Russia. Differences in metabolic phenotype should help us tailor therapeutic and preventive interventions so it is important to understand them. It is noteworthy that patient's diet was mostly unhealthy (inappropriate fat and protein content). INCORPORATION OF AFREZZA® INTO THE TYPE 2 DIABETES SIMULATOR, R. Visentin1, T. Klabunde2, M. Grant3, C. Dalla Man1, C. Cobelli1, 2Sanofi-Aventis Deutschland GmbH, R&D LGCR/Structure-Design & Informatics, Frankfurt, Germany 3Mannkind Cooperation, Danbury, USA. Ospedale Niguarda, SSD Diabetologia, Milano, Italy, 2AO Treviglio, Diabetologia, Bergamo, Italy, 3Universita degli Studi, Dip. Metabolic improvements were determined in all subjects. Conclusion: Our results suggest that the ACCU-CHEK® Connect system is easy to learn/use and helpful for T1D children/ adolescents and their parents/caregivers in managing their diabetes. Previous calibration procedure took about 2.5 hours and required a minimum of seven invasive measurements. Conclusion: The nocturnal hypoglycemia benefit of Gla-300 vs Gla-100 is confirmed with both windows. Results: SAXS analysis revealed that niacinamide increased the percentage of monomeric IAsp by *34.3% (±7.4%) in diluted formulations mimicking s.c. conditions after injection. length of the needles enabled extraction at the same time as they were short enough to not generate discomfort during sampling, as they didn't reach any sensory receptors. The aim was to evaluate whether an intervention with GSD-Y in groups of adolescents starting on CSII and their parents leads to decreased HbA1c and fewer diabetes-related family conflicts. The survival advantage of phosphate-binding agent prescription remained statistically significant after propensity score matching analysis. Conclusion: These initial findings suggest that fear of hypo-/ hyperglycemia in patients with type 1 diabetes are to some extent a reflection of actual metabolic challenges in daily diabetes management. In addition, participants recorded a single daily rating of hypo-/hyperglycemic fear, carbohydrate consumption, and insulin bolus units. The chipset was manufactured in monocrystalline silicon using micro mechanical system (MEMS) technology. Background and Aims: The Artificial Pancreas (AP) system based on the Modular Model Predictive Control algorithm (MMPC) running on the wearable platform Diabetes Assistant (DiAs, University of Virginia) has been successfully used for 2 months in adults patients reducing time-in-hypo (CGM < 70 mg/ dL) and increasing time-in-target (70-180 mg/dL) with respect to Sensor Augmented Pump therapy (SAP). Background and Aims: Sleep restriction and changes in sleep architecture can be associated with impaired control of diabetes mellitus, predominantly in adults. However, this intention is influenced by their attitude towards new technologies, easy of use and compatibility of the AP, and their social environment. Sehen Sie sich das Profil von Arun Kumarasamy im größten Business-Netzwerk der Welt an. Meals were identical and accompanied by pre-meal boluses. Clinical Laboratory Standards Institute (CLSI), a) > 95% of the results must be within either ±12 mg/dL of the analyzer result, for samples <100 mg/dL, or ±12.5% for samples, b) < 2% of results present differences > 20% when glucose is. Results: Patients were aged 50 ± 15 years, with 57.2% male and 26% T1D. Autonomic tests can be used as a screening in patients with DM duration over 5 years. WHO IS THE MAIN BENEFICIARY OF INSULIN PUMP THERAPY: LONG-TERM OUTCOME IN CHILDREN WITH TYPE 1 DIABETES? These conversations often include suggestions that are inconsistent with their physicians' recommendations, including the use of CGMs for self-management. IrJ: -t}î(-ilîi yttC^1. Pilot feasibility studies demonstrated near-normal overnight glucose control (85-100% time within the target range of 3.5-7.8mmol/l), during early and late gestation. Background and Aims: Data about continuous subcutaneous insulin infusion (CSII) treatment in clinical practice conditions are limited. CSII. Results: Results showed that 0.2% DC in diet could reduce TC by 21%, similar to that of SI (19%). US-Amerikanisches Staatsexamen in Medizin (United States Medical Licensing Exam) Step 1 und Step 2 CK in Frankfurt, Step 2 CS in Philadelphia (USA) und Step 3 in New Jersey (USA) Beruflicher Werdegang. Method: In a laboratory study, fingertip blood samples from 100 subjects with diabetes were tested in duplicate using each of 3 test strip lots. Every 3. months, HbA1c was determined by an agglutination inhibition immunoassay. Die Approbation erfolgte 1985, die Promotion 1986. Abteilungen für Innere Medizin. Fachkunde Koloskopie. Improving injection comfort therefore represents a particular area of recent technological research. This fear can create a great tension and conflicts in family relationships. Basal-bolus insulin therapy (BBI) is recommended for inpatient diabetes management of non-critically ill patients on empirical basis. Background and Aims: Cadaba farinosa leaves are being used locally as natural folk medicine for the treatment of diabetes but until now no scientific investigation has been reported of its potential anti-diabetic effect. For GV calculation we used the data of the first 4 months after sensor-augmented pump (SAP) initiation. Dr. Slawomir Trudnowski. There is sound evidence that patients can lower their HbA1c when using this technology, and spend less time in hypoglycaemia. Background and Aims: Assessing the reduction of complications and associated costs with continuous subcutaneous insulin infusion (CSII) versus multiple daily injections (MDI) in uncontrolled type 2 diabetes patients (T2D) in Sweden. Two therapies were compared: 1) standard SMBG-based, and 2) non-adjunctive CGM-based, with insulin bolus increased/decreased by P% when an increasing/decreasing glucose trend was detected by CGM. Repeated CGMS profiles were predictive of worsened metabolic control. SOCIAL NETWORK AS A USEFUL INFORMATION RESOURCE FOR TYPE 1 DIABETES (T1D) PATIENTS AND THEIR DOCTORS, E. Shafranskaya1, E. Patrakeeva2, N. Novoselova3, 1The Center of Family Planning and Reproduction, Endocrinology, Saint-Petersburg, Russia 2Saint-Petersburg Medical University, Endocrinology, Saint-Petersburg, Russia, 3Federal Almazov North-West Medical Research Centre, Endocrinology, Saint-Petersburg, Russia. DO TYPE 1 DIABETIC PATIENTS REALLY WANT AN ARTIFICIAL PANCREAS ? The data analysis was conducted for doses at start-up (0-2nd hr), during transition-to-stabilization (2nd-4th hr) and stabilization (15th-20th hr) delivery phases. Results: The mean score for HFS-II and DTSQ was 0.99±0.5 (range 0-2.7) and 29.7 ±4.8 (range 11-36), respectively. Conclusion: DJBL seems to be an efficient and safe endo-scopic and completely reversible bariatric procedure in most severely obese adolescents with obesity complications. CP loss was assessed using SITAR, which treats the individuals' serial AUC values plotted against time as 'growth curves'. Model parameters were estimated using the Markov chain Monte Carlo approach within a hierarchical Bayesian model framework. La Gerche3, A.J. Intuitive visual interface for HCP and CGM-users and evaluation of the usability for all user categories is needed. Method: This study is half-time results from a prospective RCT including 39 adolescents aged 12-18 years starting on CSII and their parents. Regarding the approach applied in the system presented, our aim is to find the best possible combination of reminders and alerts and implement these processes as fully automatic. 6482 BG values from 60 T1DM patients in a previously published study are used to develop the, 15 20 25 30 35 40 .35 50 55 AO 65 70 75 00 05 90 95 1001051101Ï5120125130135140 MAFIC [%]. The AP significantly reduced time-in-hypo with respect to SAP, 0.00%[0.00-2.22] vs 2.19%[0-12.3], p-value = 0.002, without significant worsening of time-in-target, 55.97%(22.53) vs 59.69% (21.24), p-value = 0.422, nor of time-in-tight-target (80-140 mg/dl), 31.27% (20.23) vs 33.02%(19.80), p-value = 0.668. CAN can occur before DM is evident clinically. Conclusion: The Yale protocol shows better average glycemia, more time spent in normoglycemia, less time spent in hy-poglycemia and less glycemic variability as compared to the Leuven protocol, but was not independently associated with strict glycemic control. *In a subset of n = 15 patients, glucometers were downloaded during outpatient visits and SMBG values in the prior 3 months were analyzed. Of the 257 women, 99 had a caesarean section (38.5%). IrKulIn 'i method. 2Rainer Clinical Research Center, Clinical Research, Background and Aims: To arrive at appropriate insulin delivery decisions, hybrid closed-loop (HCL) systems require input from continuous glucose monitoring (CGM) sensors and from users who provide the system with estimates of upcoming carbohydrate intake (meal announcements). All participants were subjected to thorough clinical assessment, laboratory investigations and glucose variability calculation using the mean amplitude of glucose excursions (MAGE index) and continuous glucose monitoring (CGM) for a sample of patients. Conclusion: Faster aspart showed an enhanced early exposure and action compared with IAsp in CSII. Post stress, the biological potency of insulin was confirmed to remain above acceptable levels. CI]: - 0.99 [-1.95; -0.03]; Table). Technologically advanced metformin formulation can address, the unmet medical needs; potentially improve overall experience, minimize abdominal discomfort, patient compliance and adherence, EVALUATION OF ECONOMIC BURDEN OF TYPE 1 AND TYPE 2 DIABETES PATIENTS ON MULTIPLE DAILY INJECTION THERAPY COVERED UNDER U.S. EMPLOYER-BASED COMMERCIAL HEALTH PLANS, 1Medtronic, Health Economics and Reimbursement, Northridge, USA. 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